Call: +1-614-557-6075, main number - voicemail / +1-216-551-3643 | Fax: +1-614-453-8222 / +1-614-367-0023

Please leave a message on our recorded line



"The treatment we offer to our patients is the biggest secret to our success. By giving them the deserved respect and care, Comprehensive Pain Management Institute, aims to ensure that they get back to full life by applying the most modern, scientific and evidence based pain relief and treatment methods."

- Dr. Leon Margolin

Dr. Leon Margolin MD, PhD, FAPMR, FAPM

  • More than 30 publications (including a research manuscript), recent original study performed at the practice accepted for presentation at the national meeting, request for 2nd manuscript being processed

  • Physician’s Recognition Award from the American Medical Association (2008, 2014), Resident/ Fellow Award from the American Society of Regional Anesthesia and Pain Medicine

  • Two Certificates of Merit of the American College of Physicians, the Medical Society of Pennsylvania Award, the Pfizer Scholars in Pain Management Award, Patient’s Choice Award (several years including 2019).

  • Most Compassionate Physician Award (several years) and “Top Ten Physicians” Award in Pain Medicine (2014).


  • America's Most Honored Professionals Award (2017, 2018, 2019) 1% percent ranking.

Unique professional credentials:

  • Double Board Certification by Board Certified by the American Board of Physical Medicine and Rehabilitation and Fellowship training and Board-Certified in Pain Medicine. 

  • Additional training by The American Academy of Addiction Medicine.

  • Training/courses in Neurology by AANEM and Radiology (MRI and X rays reading).

  • Lab Director training and certification by CLIA/COLA.

“Making a difference- how many opioid deaths are too many?” Dr. Leon Margolin's interview with NBC News March 2022

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Dr. Leon Margolin's interview with NBC news

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Dr. Margolin's Presentation at the Ohio Opioid Task Force

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Methods for COVID Prevention - Presentation at the International Meeting

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Dr. Margolin published a study in collaboration with Dr. David Streem (Chief of Psychiatry and Medical Director of the Alcohol and Drug Recovery Center (Lutheran Hospital Division), Cleveland Clinic Foundation) on opioid epidemic:

Dr. Margolin’s publication in Medical Archives of European Society of Medicine on food addiction:

Our study on COVID-19 prophylaxis published in a peer reviewe journal

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These are final HTML and PDF versions:

20-Week Study of Clinical Outcomes of Over-the-Counter COVID-19 Prophylaxis and Treatment:

Our practice always advocated for implementing screening and brief intervention (SBIRT) and other pain management services even when insurance and government agencies mistakenly labeled them “not allowable”. Please see the white paper link below. Using SBIRT and other tools our practice has diagnosed and referred to addiction treatments close to 2500 individuals over the last 11 years.

A 2019 study published in the April addition Pain Medicine News shows that more Americans die from opioid epidemic than from car accidents. In our Youtube channel, our goal is to educate patients and the general public on how to keep yourself and your loved one safe. Email us questions using the button below. You can also fax your questions to 1-614-453-8222 (Attn: Dr. Margolin) Please do not include any sensitive or protected health care information.

This e-mail and fax should NOT be used for record requests or billing inquiries.


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CPMI is one of the few pain management teams in Central Ohio who was able to pass the review test and obtain the license according to the new narcotic prescriptions law (HB-93).

Dr. Margolin is also currently accredited to recommend medical marijuana to patients.CPMI has the set up to evaluate your pain comprehensively and offer the needed treatment.


Top 3 Pain Management Doctors in Columbus, Ohio- 2024

Best of Mayfield Heights, Ohio


Best of Columbus


Top 3 Pain Management Doctors in Columbus, Ohio- 2023

Certificate of Excellence 2023



TMedPM 2022 Certificate

CAM Therapies 2021 E-poster Participation

CAM Therapies 2021

Ohio top doctors award 2021

Top 3 Pain Management Doctors in Columbus, Ohio- 2021

Physician's Recognition Award, 2020-2021

Best Pain Management Doctors in Columbus

Best Pain Management Doctors in Columbus.

Patients Choice Award 2020

Best of 2020 Columbus

On-Time Doctor Award 2019

Patient Choice Award 2019

Patient Choice Award 2019

Top Pain Medicine Specialist 2019

America's Most Honored Prof. 2018


Compassionae Dr. Award 2018

Top 10 Doctor 2014

Certificate of Achievemet 2006

Certificate of Achievement


Academy of Medicine of Richmond

The Fourteenth Annual Resident Research Paper Competition


American college of physicians -American society of internal medicine


American college of physicians


Comprehensive Pain Management Institute Welcomes You.

Our scientific based medicine approach and comprehensive treatment and management can fix a wide range of conditions and restore you to full life. These Conditions and treatment include:

  • Neuropathy
  • Post Radiation and Chemotherapy Pain
  • Sciatica and Degenerative Disc Disease
  • Intercostal Neuritis/Rib Pain
  • Sacral pain
  • Hip, Knee, Ankle, Shoulder, Wrist Pains
  • RadicularPain
  • Radiofrequency Ablation
  • Testicular/Gynecological Pain
  • Reflex Sympathetic Dystrophy
  • Epidural injections
  • Facet injections/Medial Branch Blocks
  • Peripheral joint injections
  • Facet Joint Injections
  • Trigger Point Injections
  • Epidural Steroid Injections
  • Joint Injections
  • Ultrasound Guided Procedure
  • Peripheral Nerve Blocks
  • Suboxone Treatment
  • Medical Marijuana Evaluation

Dr. Margolin has put together a team of highly qualified and skilled practitioners in various fields of pain relief and management to always put the needs of patient first. By giving them the deserved respect and care, Comprehensive Pain Management Institute, aims to ensure that our patients get back to full life by applying the most modern, scientific and evidence based pain relief and treatment methods. 

Decreased waiting time

New Facility

Our new 6,000 ft facility has the capacity to handle more issues and accept new referrals.

Narcotic Prescription

We have the capacity to take over narcotic prescriptions for selected patients after appropriate screening and interventional pain management.

Scientific Evidence

Our goal is to offer effective pain treatments and management using highly scientific and evidence based approaches by applying stringently the State’s Medical Board Policies.

Contact Us


5245 E Main ST. Columbus

Ohio 43213

P: 614-557-6817

F: 614-453-8222



25901 Emery Rd suite 108

Warrensville Heights OH 44128

P: 216-551-3643

F: 614-453-8222